Long-term potentiation in hippocampal oriens interneurons: postsynaptic induction, presynaptic expression and evaluation of candidate retrograde factors
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چکیده
منابع مشابه
Long-term potentiation in hippocampal oriens interneurons: postsynaptic induction, presynaptic expression and evaluation of candidate retrograde factors
Several types of hippocampal interneurons exhibit a form of long-term potentiation (LTP) that depends on Ca(2+)-permeable AMPA receptors and group I metabotropic glutamate receptors. Several sources of evidence point to a presynaptic locus of LTP maintenance. The retrograde factor that triggers the expression of LTP remains unidentified. Here, we show that trains of action potentials in putativ...
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Several subtypes of interneurons in the feedback circuit in stratum oriens of the hippocampus exhibit NMDA receptor-independent long-term potentiation (LTP) at glutamatergic synapses made by local pyramidal neurons. LTP has been reported with both "Hebbian" and "anti-Hebbian" induction protocols, where high-frequency presynaptic stimulation is paired with either postsynaptic depolarization or h...
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Inhibition provided by local GABAergic interneurons (INs) activates ionotropic GABAA and metabotropic GABAB receptors (GABABRs). Despite GABABRs representing a major source of inhibition, little is known of their function in distinct IN subtypes. Here, we show that, while the archetypal dendritic-inhibitory somatostatin-expressing INs (SOM-INs) possess high levels of GABABR on their somato-dend...
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Hippocampal cells often fire prolonged bursts of action potentials, resulting in dynamic modulation of postsynaptic responses; yet long-term potentiation (LTP) has routinely been studied using only single presynaptic stimuli given at low frequency. Recent work on neocortical synapses has suggested that LTP may cause a "redistribution of synaptic strength" in which synaptic responses to the firs...
متن کاملPresynaptic Expression of Long-Term Potentiation
methods that allow high spatial resolution challenge the notion of an entirely postsynaptic locus of expression. By directly visualizing presynaptic release at individual CA1 synapses using FM1-43, Zakharenko et al. (51) observed enhanced rates of synaptic vesicle recycling following induction of a form of LTP that depends on both NMDA receptor and L-type Ca2+ channel activation. Within the sam...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2014
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2013.0133